Abstract Library

#3381 Time to reclassify gastric carcinomas of diffuse type to neuroendocrine carcinomas

Introduction: The difference between adeno- and neuroendocrine carcinomas has been disputed for decades. Occurrence of neuroendocrine tumor cells in adenocarcinomas has been recognized, but the distinction between them has been made upon a certain number of tumor cells with a neuroendocrine marker. The number of positive cells depends upon the sensitivity of the method. Carcinogenesis generally results in loss and not gain of function. New gene expression of markers specific for a cell type seldom occurs.

Conference:

Presenting Author: Waldum H

Authors: Waldum H, Mjønes P,

Keywords: adenocarcinoma, neuroendocrine carcinoma, neuroendocrine tumor (NET), classification,

#622 Evaluation of Mucin and Neuroendocrine Expression in Diffuse Gastric Cancer with Signet Ring Cell Morphology

Introduction: A proportion of diffuse gastric carcinoma, according to the Lauren classification system, has signet ring cell morphology. Signet ring cells are characterized by a peripherally placed nucleus and a central amorphous substance, which is reported to be mucin based on Periodic Acid Schiff positivity (PAS). PAS is not a specific staining method for mucin. Neuroendocrine expression has previously been reported in tumor cells in diffuse type gastric cancer.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author: Sørdal �

Authors: Sørdal �, Qvigstad G, Nordrum I, Waldum H,

Keywords: gastric signet ring cell carcinoma, mucin, neuroendocrine markers, PAS,