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#680 Role of EGF Pathway in Regulating Bronchial Carcinoid Cell Proliferation

Introduction: Bronchial carcinoids (BC) are rare neuroendocrine tumors. Surgery is not feasible for infiltrating and metastatic disease. Medical therapy is often tried but is represented by chemotherapy and radiation, while somatostatin analogues are employed for symptomatic control. It is necessary to identify new molecules capable of providing medical treatment in cases for which surgical removal is not feasible. EGF, TGFα are growth factors which were demonstrated to be important in neuroendocrine tumors. EGF and TGFα bind to the EGF receptor and lead to the transcription of genes that regulate cell proliferation.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Gagliano T, Bellio M, Molè D, Gentilin E, Minoia M,

Keywords: EGF, EGFR, BC,