Abstract Library
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ENETS Abstract Search
Introduction: Metastatic neuro-endocrine tumors (MNETs) are rare and their management are complex. To standardize therapeutic strategies in France, a national network of clinicians (RENATEN) has been created, composed of 17 expert centres.
Conference: 13th Annual ENETSConcerence (2016)
Presenting Author:
Authors: Lesouef M, Bouhier-Leporier K, Pham A, Granier S, Dupont B,
Keywords: Metastatic Neuro-Endocrine Tumors, Epidemiological Characteristics,
#1312 Epigenetic Remodeling upon DAXX and ATRX Loss in Pancreatic Neuro-endocrine tumors (pNETs)
Introduction: DAXX and or ATRX loss occur in 40% of sporadic pNETs. DAXX and ATRX participate in the cell epigenetic status maintenance. Epigenetic changes influence gene expression, function of telomeres and genomic stability. We hypothesize that DAXX/ATRX loss drives tumor progression in pNET through epigenetic changes affecting genomic stability.
Conference: 13th Annual ENETSConcerence (2016)
Presenting Author:
Authors: Marinoni I, Wiederkeher A, Pantasis S, Normand L, Wiedmer T,
Keywords: DAXX/ATRX, epigenetic, CIN,
Introduction: ATRX and DAXX mutations associated with alternative lengthening of telomeres ( ALT) phenotype have been shown as one of the major altered pathways in pancreatic neuroendocrine tumors (PanNET).
Conference: 12th Annual ENETSConcerence (2015)
Presenting Author:
Authors: Neumayer B, Normand L, Hoffmeister M, Friemel J, Perren A,
Keywords: DAXX, ATRX, Alternative lengthening of telomeres, neuroendocrine tumor, Insulinoma,