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#160 The role of T-type calcium channels in medullary thyroid carcinoma (MTC): T-type calcium channel blockers inhibit hormone secretion and induce apoptotic cell death in a human MTC cell line

Introduction: Medullary thyroid carcinoma (MTC) accounts for approximately 5-10% of thyroid cancers. In the case of tumors limited to the thyroid gland, the prognosis is generally favorable, whereas 5-year survival averages only 40% in patients with metastatic disease. In these patients, conventional chemotherapy only occasionally leads to a complete response and partial responses are observed in less than 30% of the cases. Therefore, intense efforts are currently directed toward the identification of new druggable targets for the treatment of this devastating disease.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author: Pivonello R

Authors: Pivonello R, Pivonello C, Cavaccini A, Petrillo G, De Marino G,

Keywords: medullary thyroid carcinoma, T-type calcium channels, mibefradil, calcitonin, apoptosis,