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#860 Expression and Prognostic Role of CXCR4/CXCL12/CXCR7 and mTOR Pathways in Neuroendocrine Tumors (NETs)

Introduction: The chemokine receptor CXCR4 interacts with the ligand CXCL12 to exert proliferative and chemotactic effects. CXCR4 activates mTOR through phosphorylation of its two effectors downstream:4EBP1and S6K

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Circelli L, Sciammarella C, Faggiano A, Tafuto S, Pezzullo L,

Keywords: Chemokine, mTOR, NETs, clinical outcome,