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#1877 TSC22D1 Expression and Association with Clinic-Pathological Features in Bronchial Carcinoids

Introduction: Bronchial carcinoids (BC), typical (TC) or atypical (AC), are rare neoplasms arising from neuroendocrine cells spread in the respiratory epithelium Microarray data analysis obtained comparing a pool of TC with a pool of AC samples showed TSC22D1 down-regulation in AC samples. The role of TSC22D1 in neuroendocrine tumors is unknown.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Zatelli M

Authors: Falletta S, Gentilin E, Riva E, Bresciani G, Degli E,

Keywords: TSC22D1, bronchial carcinoids, aggressiviness,

#1301 Role of TSC22D1 (TGFβ-Stimulated Clone 22 Domain Family Member 1) in Bronchial Carcinoids

Introduction: Neuroendocrine tumors (NETs) include bronchial carcinoids, either typical (TC) or atypical (AC). Tsc22d1 encodes for a member of TSC22 domain family of leucine zipper transcription factors; the protein (TSC22D1) is stimulated by TGFβ. Microarray data analysis obtained comparing a pool of TC tissue specimens with a pool of AC tissue specimens shows TSC22D1 down-regulation in AC samples. These data were confirmed by real time PCR and Western blot in vitro models of TC (NCI-H727 cells) and AC (NCI-H720 cells)

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author:

Authors: Falletta S, Gagliano T, Di Pasquale C, Benfini K, Riva E,

Keywords: TSC22D1, bronchial carcinoid, TGFβ,