TSC22D1 Expression and Association with Clinic-Pathological Features in Bronchial Carcinoids

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Introduction: Bronchial carcinoids (BC), typical (TC) or atypical (AC), are rare neoplasms arising from neuroendocrine cells spread in the respiratory epithelium Microarray data analysis obtained comparing a pool of TC with a pool of AC samples showed TSC22D1 down-regulation in AC samples. The role of TSC22D1 in neuroendocrine tumors is unknown.

Aim(s): To evaluate TSC22D1 protein levels in BC tissues and the association between its expression with clinical and pathological characteristics of the patients.

Materials and methods: TSC22D1 protein levels were evaluated in BC tissues derived from 20 patients. Molecular, clinical-and pathological characteristics of the patients were collected. TSC22D1 expression was correlated with sex, age, Ki-67, tumor grade, nodal stage and progression-free survival (PFS).

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Zatelli M

Authors: Falletta S, Gentilin E, Riva E, Bresciani G, Degli E,

Keywords: TSC22D1, bronchial carcinoids, aggressiviness,