Abstract Library
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ENETS Abstract Search
Introduction: Surufatinib is a targeted inhibitor of tyrosine kinases VEGFR1, 2, & 3, FGFR1, and CSF-1R. The safety profile was favorable in 2 completed studies (NCT02133157, NCT02267967) conducted in China. A recent phase 3 placebo controlled study (NCT02588170) confirmed safety, and demonstrated superior efficacy (PFS: 9.2 v 3.8 months) of Surufatinib in Chinese pts with advanced extra-pancreatic NETs (epNET).
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author:
Authors: Dasari A, Paulson S, Sung M, Tucci C, Kauh J,
Keywords: Neuroendocrine Tumors, Pancreatic, Surufatinib,
#2168 Phase II Trial of Cabozantinib in Patients with Carcinoid and Pancreatic Neuroendocrine Tumors
Introduction: Activation of VEGFR2 and MET is implicated in driving growth of NET. Cabozantinib inhibits VEGFR2, MET, AXL, RET.
Conference: 15th Annual ENETSConcerence (2018)
Presenting Author:
Authors: Chan J, Faris J, Murphy J, Blaszkowsky L, McCleary N,
Keywords: cabozantinib, pancreatic neuroendocrine tumor, carcinoid, phase II,
Introduction: The expression of vascular endothelial growth factor Receptor 3 (VEGFR3) and phospho-VEGFR3 (pVEGFR3) in gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) and their clinical significance are still unknown.
Conference: 15th Annual ENETSConcerence (2018)
Presenting Author: Zhang Y
Authors: Zhang Y, Chen L, Lin Y, Chen M, Chen J,
Keywords: gastroenteropancreatic neuroendocrine neoplasms, vascular endothelial growth factor Receptor 3, expression, clinical significance,
Introduction: Sst5TMD4, which is derived from a non-canonical splicing process of sst5 receptor, is overexpressed in several endocrine tumors and associated with a worse prognosis.
Conference: 14th Annual ENETSConcerence (2017)
Presenting Author:
Authors: Diaz Perez A, Martínez-Fuentes A, García-Carbonero R, Luque R, Jimenez-Fonseca P,
Keywords: somatostatin receptor, neuroendocrine tumors,
Introduction: Angiogenesis plays an important role in tumour growth and disease progression. VEGF is a angiogenesis-stimulating factor. VEGFR2 has antiangiogenic properties.
Conference: 13th Annual ENETSConcerence (2016)
Presenting Author:
Authors: Rosiek V, Kos-Kudła B, Zemczak A,
Keywords: neuroendocrine neoplasms, VEGF, VEGFR2,