Abstract Library

#1741 Complete Remission of Hepatic Metastasis after Total Gastrectomy for a Gastric Carcinoid Tumor Type 1: A Case Report

Introduction: A 58-year-old woman was referred to our hospital for hepatic lesions and thickening of the walls of the stomach detected by abdominal CT scan. An upper GI endoscopy showed a lesion of the body of the stomach and the histopathologic exam documented a well differentiated NET. 68Ga-DOTATOC PET showed pathologic uptake in the stomach and in the liver (3 lesions). Circulating chromogranin A and gastrin were 596 ng/ml and 2283 pg/ml respectively

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Smiroldo V

Authors: Smiroldo V, Carnaghi C, Tresoldi A, Lania A, Bonifacio C,

Keywords: gastric, NET, complete remission, gastrin,

#975 Electron Microscopy of Pancreatic Beta Cell Neuroendocrine Tumors (NETs) in Multiple Endocrine Neoplasia Type 1 (MEN1) Knockout Mice Reveal an Adenomatous Phenotype with Depletion of Insulin Granules and Increased Mitochondrial Content

Introduction: Insulinomas are β cell neuroendocrine tumors (NETs) that secrete insulin, and ~4% of insulinoma patients have multiple endocrine neoplasia type 1 (MEN1). One in ten MEN1 patients present with an insulinoma. Previous reports describe insulinomas as possibly having typical granules (46.4%) or atypical smaller granules (34.3%), both associated with adenomas, or agranular cells (14.3%) associated with carcinomas. MEN1 knockout (Men1+/-) mice develop pancreatic NETs that are mostly insulinomas, and their ultrastructural phenotype is unknown. We hypothesized that these may resemble the adenoma phenotype with atypical granules.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Walls G, Clark A, Thakker R,

Keywords: GEP-NET,