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#3714 CT derived body composition index analysis in metastatic NET patients treated with mTOR inhibitor

Introduction: Neuroendocrine tumors (NETs) are rare neoplasms frequently characterized by an upregulation of the mammalian rapamycin targeting (mTOR) pathway resulting in uncontrolled cell proliferation. The mTOR pathway is also involved in skeletal muscle protein synthesis and in adipose tissue metabolism. Everolimus inhibits the mTOR pathway, resulting in blockade of cell growth and tumor progression.

Conference:

Presenting Author: Fatima A

Authors: Fatima A,

Keywords: mTOR, metastatic NET, body composition index, skeletal muscle protein,