Abstract Library

#3764 Therapeutic response of ACTH-dependent ectopic Cushing's syndrome to low doses of osilodrostat

Introduction: Cushing's disease (CD) is the main cause of ACTH-dependent Cushing's syndrome (ACTH-CS). In 5–15% of cases, ACTH/CRH production is ectopic and is caused by neuroendocrine tumors of the lung, thymus, or pancreas, medullary thyroid carcinoma, and pheochromocytoma. Diagnostic imaging can locate the primary tumor; however, between 8-22% the cause is unknown. The FDA approved Osilodrostat for the treatment of inoperable or refractory CD, its use in high doses in patients with ectopic CS has been reported.

Conference:

Presenting Author:

Authors: González Devia D, Florez-Romero A, Rojas-Camacho J, Herrera Almario G, Jimenez Hakim E,

Keywords: ACTH-dependent Cushing's syndrome, Osilodrostat, Adrenal steroidogenesis inhibitors, Ectopic ACTH Cushing´s syndrome,

#3679 Ectopic Cushing's syndrome caused by a well differentiated ACTH-secreting neuroendocrine tumor of the ileum

Introduction: Ectopic Cushing syndrome is responsible for 20% of cases of Cushing’s syndrome (CS); with presentation ranging from undetectable lesions to metastatic carcinomas. Ectopic ACTH syndrome (EAS) of intestinal origin is very rare, only five patients have been reported. In this article, we report a case of an ileal ACTH-secreting Neuroendocrine tumor.

Conference:

Presenting Author:

Authors: González Devia D, Llanos-Orozco N, López-Mesa de Mesa J, Fierro-Maya L, Cuéllar-Cuéllar A,

Keywords: Ectopic ACTH syndrome, Midgut Neuroendocrine Tumor, Ectopic Cushing syndrome, Neuroendocrine Tumor, Small intestine tumor,

#2885 Ectopic Neuroendocrine Carcinoma: An Occult Source of ACTH

Introduction: About 250 cases of ectopic ACTH-producing neuroendocrine carcinoma (ACTH-NEC) have been reported; however metastatic ACTH-NEC of unknown primary is very rare. Usually are characterized by having a large cell, small cell, poorly differentiated or anaplastic cell, and Ki-67 index between 40-90%.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Huertas Gnecco B

Authors: Huertas Gnecco B, González Devia D, Alvaréz Figueroa J, Aguirre Matallana D, Cañón Solano D,

Keywords: Ectopic ACTH production, Cushing’s syndrome, Neuroendocrine carcinoma, Paraneoplastic Cushing syndrome, Ectopic Cushing´s syndrome,

#2233 Potential Effects of Ketoconazole on ACTH-Producing and Non-ACTH-Producing Neuroendocrine Tumors

Introduction: Prolonged biochemical remission after treatment with steroidogenesis inhibitors has been described in patients with Cushing’s syndrome due to ectopic adrenocorticotropin hormone (ACTH) production. Some studies have suggested antiproliferative and apoptotic effect of ketoconazole in human cancer cells.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Herrera-Martínez A

Authors: Herrera-Martínez A, Feelders R, Castaño J, Van Dungen R, Dogan-Oruc F,

Keywords: ACTH- and non-ACTH producing NETs, ketoconazole, somatostatin analogs, apoptosis, cytotoxicity,

#2193 Advanced Gastric Neuroendocrine Carcinoma: A Diagnostic and Management Conundrum

Introduction: Gastric neuroendocrine carcinomas are rare tumors with a high malignant trait and poor prognosis. Endogenous hypercortisolism associated with neuroendocrine carcinomas can have a negative impact on patients' survival.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author:

Authors: Lambrescu I, Martin S, Nitipir C, Terzea D, Cima L,

Keywords: gastric neuroendocrine carcinoma, hypercortisolism, Cushing disease, ectopic ACTH,