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#1202 Role of Amplifications in the PIK3/Akt/mTOR-Pathway in Neuroendocrine Tumors of the Small Intestine

Introduction: Amplifications in the PIK3/Akt/mTOR pathway can lead to increased proliferation and reduced apoptosis, resulting in the development of various cancers. Recently, amplifications of Akt1/2, PDGFRα/β and mTOR in small intestine neuroendocrine tumors (siNET) have been shown.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author:

Authors: Hoffmeister M, Sperveslage J, Anlauf M, Petersen K, Gress T,

Keywords: NET, gene amplification, mTOR pathway,