Abstract Library

#4157 Decoding and targeting of metabolic heterogeneity in pancreatic neuroendocrine tumors (PanNETs): MCT1 and MCT4 in the crosshair for precision therapy

Introduction: Mechanisms driving progression from indolent to aggressive and metastatic disease in PanNET are largely unknown. Recent transcriptome and epigenome analyses suggest a stepwise progression model leading to enhanced proliferation, de-differentiation, and metabolic reprogramming. However, the metabolic landscape at different stages and the therapeutic potential of targeting metabolic proteins remain largely uncharacterized.

Conference:

Presenting Author: Sadowski M

Authors: Bräutigam K, Straub J, Bihi A, Andreasi V, Kirchner P,

Keywords: metabolic heterogeneity, 3D model, precision medicine, metabolic subtype, PanNET, hypoxia, lactate efflux, microvessel density, MCT1/MCT4,

#3713 Methylmalonic acid activates INHBA induced epithelial-mesenchymal transition and promotes the cancer progression by TGF-β signalling pathway in pancreatic neuroendocrine neoplasm

Introduction: Metabolic reprogramming is a well-recognized hallmark of cancer progression, especially the process of tumor metastasis. However, the role of metabolic alteration and its potential mechanism in pancreatic neuroendocrine neoplasm (pNEN) with metastasis remain elusive.

Conference:

Presenting Author: Hu C

Authors: Hu C, Ye M, Bai J, Tang Q,

Keywords: metabolic reprogramming, pancreatic neuroendocrine neoplasm, methylmalonic acid, INHBA, TGF-β, epithelial-mesenchymal transition,