Abstract Library
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ENETS Abstract Search
Introduction: Peptide receptor targeting has proven to be a pivotal tool for diagnostic imaging and radioligand therapy of neuroendocrine neoplasms (NENs), which frequently express somatostatin receptors (SSTRs) on their cell surface. However, up to 30 % of NEN patients do not benefit from SSTR-based approaches, others develop a resistance.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author:
Authors: Grötzinger C, Exner S, Schuldt C, Du J, Sachindra S,
Keywords: receptor, targeting, imaging, prrt, peptide, angiotensin,
Introduction: Neuroendocrine differentiation and an aggressive phenotype is an important feature of castration-resistant prostate cancer (CRPC). Current biomarkers are unable to detect these advanced, treatment refractory variants.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author: Modlin I
Authors: Modlin I, Kidd M, Rahbar K, Malczewska A, Rajwa P,
Keywords: Biomarker, NETest, PSA, prostate cancer, neuroendocrine phenotype, castration-resistance, neuroendocrine,
Introduction: DNA-targeting agents are the main treatment of aggressive pulmonary and pancreatic neuroendocrine carcinomas (NEC). FOXM1 is a transcription factor controlling cell proliferation and DNA repair pathways, playing therefore an important role in tumor progression and chemoresistance.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author: Cros J
Authors: De Rycke O, Raffenne J, Lacombe C, Hentic O, Gounant V,
Keywords: neuroendocrine carcinoma, FOXM1, DNA repair, anti-tumor drug,
#2834 Tumor-Promoting Effects of the Transcriptional Regulator CUX1 in PanNET
Introduction: Previously, we identified CUX1 as mediator of metastatic behaviour and poor differentiation in human insulinomas. CUX1 mediated tumor-promoting functions via enhancing proliferation, resistance to apoptosis and angiogenesis in-vitro and in-vivo.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author: Weißbach J
Authors: Weißbach J, Schmitz R, Haybäck J, Perren A, Blank A,
Keywords: CUX1, RIP1Tag2, DAPK1, Apoptosis, Tumor Progression,
#2827 Characterization of Epigenetic Modulation in Pancreatic Neuroendocrine Neoplasms
Introduction: Pancreatic neuroendocrine tumors (PanNETs) represent a rare and heterogeneous tumor entity. Despite advances in therapy cancer progression and resistance mechanisms are still challenging. Recent genome wide sequencing analyses in PanNETs identified a large number of mutated genes involved in epigenetic modulation.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author: Schmitz R
Authors: Schmitz R, Weißbach J, Kleinlein J, Schrader J, Grabowski P,
Keywords: PanNET, HDAC-Inhibition, SOCS3, lncRNA, Macrophages,