Abstract Library

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#3450 Re-cellularised human pancreas 3D scaffolds as a novel disease model of pancreatic neuroendocrine tumors (pNETs)

Introduction: A lack of preclinical models of pNETs challenges understanding of complex interactions between cancer cells and their stroma. Traditional in vitro disease models such as 2D cultures however, induce phenotypic and functional drifts consequent of their removal from the native, tissue specific niche. Culturing pNET cells in their native tissue recapitulates specific cell-ECM interactions and tissue remodeling processes.

Conference:

Presenting Author: Ney A

Authors: Ney A, Sedlak E, Garcia-Sampedro A, Hall A, Bhamra A,

Keywords: Disease model, pancreatic neuroendocrine tumor, tissue remodeling, stroma, biomarker,