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#1436 Up-Regulation of the Immunoregulatory Enzyme Indoleamine-2,3-Dioxygenase (IDO) with Consecutive Tryptophan Depletion Predicts Death in Patients with Neuroendocrine Neoplasia

Introduction: Data from a considerable number of malignancies demonstrate that depletion of the essential amino acid tryptophan via induction of the immuno-regulatory enzyme Indoleamine-2,3-dioxygenase (IDO) serves as an important tumour escape strategy and is of prognostical importance.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: unknown u

Authors: Pschowski R, Pape U, Fusch G, Jann H, Maasberg S,

Keywords: IDO-1, inflammation, tryptophan catabolites, predictor, biomarker,