Abstract Library

#855 Extrapulmonary Small Cell Neuroendocrine Carcinoma of the Colon in an 18-Year-Old Girl

Introduction: Extrapulmonary small cell carcinoma (EPSCC) is a very rare aggressive malignant tumor typical for older age. Prognosis of EPSCC remains very poor, with three years OS 38% and five years OS less than 13%. The median survival for GI localised EPSCC is only five months. Initial extent of disease is the most sensitive prognostic factor.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author: Bajciova V

Authors: Bajciova V, Kren L, Oltova A,

Keywords: colon EPSCC, young age,

#453 Activation of Hedgehog Pathway in Neuroendocrine Tumor

Introduction: Neuroendocrine tumors (NETs) are rare tumors and often follow an indolent course, especially the tumors of low-to-intermediate grade. The genetic etiology of sporadic NET is largely unknown. It is well-known that a significant number of patients with NETs may have harbored the slow-growing lesions since very a young age, suggesting it could result from alterations of pathways involved in development. Hedgehog (Hh) signaling has been found to be important in embryonic patterning, stem cell maintenance and tissue repair; and is normally silenced in most mature adult tissue. However, it frequently undergoes gain-of-function mutations or reactivation due to ligand overproduction and has been linked to the etiology of a variety of tumors.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Dong M, Sangai T, Rashid A, Meric-Bernstam F, Yao J,

Keywords: neuroendocrine tumor, Hedgehog pathway, therapeutic target,