A molecular map of lung neuroendocrine neoplasms

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Introduction: Lung neuroendocrine neoplasms (LNEN) are understudied cancers because of their rarity, and the sample sizes of the genomic studies are limited. Recently, we performed the first multi-omic characterization of atypical carcinoids, unveiling the existence of the supra-carcinoids and providing the missing pieces for a complete molecular characterization of LNEN.

Aim(s): Integrating LNEN data from independent studies will allow drawing more meaningful conclusions and visualizing a complete molecular landscape of LNEN.

Materials and methods: We have homogenized and integrated transcriptomic data from six different LNEN studies for the four LNEN histological types using the UMAP dimensionality reduction technique. We evaluated the accuracy of the generated molecular map in regard to the main biological findings from the original studies, and geospatial quality metrics.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author:

Authors: Mathian E, Gabriel A, Mangiante L, Voegele C, Cahais V,

Keywords: carcinoid, lung cancer, neuroendocrine neoplasm, rare cancers, omics, tumor map,