Abstract Library

#3845 The lungNENomics project – A comprehensive multidisciplinary characterisation of pulmonary carcinoids

Introduction: Lung neuroendocrine tumors (LNETs) are subdivided into low-grade (typical) and intermediate-grade (atypical) carcinoids, at higher risk of developing metastases. We have previously identified 3 LNETs molecular groups with different prognoses, as well as “supra-carcinoids” with molecular profiles of higher-grade neuroendocrine carcinomas. Despite promising results, there is still no consensus on their differential diagnosis and treatment and little is known about how some tumors evolve toward more aggressive phenotypes.

Conference:

Presenting Author:

Authors: Foll M, Sexton-Oates A, Mathian E, Alcala N, Mangiante L,

Keywords: lung carcinoid, deep learning, genomic, evolution, multi-omics, spatial analyses,

#3835 Druggable growth dependencies and tumor evolution analysis in patient-derived organoids of neuroendocrine cancer

Introduction: 28% of low-grade neuroendocrine tumors (NETs) present at advanced stages and are unresponsive to therapy, pointing to a gap in our understanding of how these tumors arise and progress.

Conference:

Presenting Author: Dayton T

Authors: Dayton T, Alcala N, Moonen L, den Hartigh L, Mangiante L,

Keywords: Organoids, LCNEC, NET, pulmonary carcinoid, EGF,

#3401 Characterising aggressive pulmonary carcinoids through integrative omics analysis

Introduction: Atypical carcinoids, and our recently identified supra-carcinoids (Alcala et al. 2019) belong to the pulmonary carcinoid (PCA) group of low grade lung neuroendocrine tumors. Little is known about the underlying biology of these tumors, nor why some patients are prone to metastatic disease and tumor recurrence. To date, molecular analysis of these tumors has been limited, particularly with regard to whole-genome sequencing (WGS).

Conference:

Presenting Author:

Authors: Sexton-Oates A, Di Genova A, Alcala N, Mangiante L, Voegele C,

Keywords: pulmonary carcinoid, genome, transcriptome, epigenome, characterisation,

#3395 Changes in DNA methylation are associated with differential Orthopedia Homeobox (OTP) expression in pulmonary carcinoids

Introduction: Limited number of tumor types have been examined for Orthopedia Homeobox (OTP) expression. In pulmonary carcinoids, loss of expression is a strong indicator of poor prognosis.

Conference:

Presenting Author: Moonen L

Authors: Moonen L, Mangiante L, Leunissen D, Gabriel A, Hillen L,

Keywords: Pulmonary, neuroendocrine, carcinoid, DNA methylation, Orthopedia Homeobox,

#3235 A molecular map of lung neuroendocrine neoplasms

Introduction: Lung neuroendocrine neoplasms (LNEN) are understudied cancers because of their rarity, and the sample sizes of the genomic studies are limited. Recently, we performed the first multi-omic characterization of atypical carcinoids, unveiling the existence of the supra-carcinoids and providing the missing pieces for a complete molecular characterization of LNEN.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author:

Authors: Mathian E, Gabriel A, Mangiante L, Voegele C, Cahais V,

Keywords: carcinoid, lung cancer, neuroendocrine neoplasm, rare cancers, omics, tumor map,