Druggable growth dependencies and tumor evolution analysis in patient-derived organoids of neuroendocrine cancer

#3835

Introduction: 28% of low-grade neuroendocrine tumors (NETs) present at advanced stages and are unresponsive to therapy, pointing to a gap in our understanding of how these tumors arise and progress.

Aim(s): To generate a robust and faithful experimental in vitro system to study neuroendocrine neoplasms (NENs).

Materials and methods: We have applied the organoid culture system to study NENs.

Conference:

Presenting Author: Dayton T

Authors: Dayton T, Alcala N, Moonen L, den Hartigh L, Mangiante L,

Keywords: Organoids, LCNEC, NET, pulmonary carcinoid, EGF,