Characterising aggressive pulmonary carcinoids through integrative omics analysis

#3401

Introduction: Atypical carcinoids, and our recently identified supra-carcinoids (Alcala et al. 2019) belong to the pulmonary carcinoid (PCA) group of low grade lung neuroendocrine tumors. Little is known about the underlying biology of these tumors, nor why some patients are prone to metastatic disease and tumor recurrence. To date, molecular analysis of these tumors has been limited, particularly with regard to whole-genome sequencing (WGS).

Aim(s): In the lungNENomics project we aim to perform comprehensive multi-omic molecular, morphological, and clinical characterisation of aggressive PCA, with a particular focus on supra-carcinoids. This study will help us to understand the biological mechanisms underlying the development of these tumors, and provide insights to improve their clinical management.

Materials and methods: We have generated WGS, RNA sequencing and DNA methylation array data for PCA tumors from 91 patients, including 66 with the very rare atypical type. This represents the largest multi-omic cohort of atypical carcinoids to date. These data have been combined with previously published PCA data, to perform integrative analysis using multi-omics factor analysis.

Conference:

Presenting Author:

Authors: Sexton-Oates A, Di Genova A, Alcala N, Mangiante L, Voegele C,

Keywords: pulmonary carcinoid, genome, transcriptome, epigenome, characterisation,