A Role for Vitamin D in the Gastro-Entero-Pancreatic Neuroendocrine Neoplasms Outcome: Report on a Series from a Single Institute. 

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Introduction: Vitamin D deficiency is hypothesized to represent a risk factor in several neoplasms.

Aim(s): The aim of this study was to determine whether serum 25-hydroxyvitamin D (25-OHvitD) deficiency represents a risk factor for neuroendocrine neoplasms (NENs) and can be associated to overall survival (OS) and progression-free survival (PFS).

Materials and methods: From 2010 to 2015 138 patients with gastro-entero-pancreatic NENs (F=61, median age 63 years) were included in the study. Serum 25-OHvitD levels, measured at baseline, were defined as deficient if <20 ng/ml. In such cases 25-OHvitD supplementation was administered to the patients. The possible associations between 25-OHvitD levels and disease grading, staging, overall OS and PFS were considered. Furthermore, the possible association between 25-OHvitD supplementation and PFS or OS was evaluated by Cox’s proportional hazards regression.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Massironi S, Zilli A, Bernasconi S, Fanetti I, Cavalcoli F,

Keywords: vitamin d deficiency, net,