A single institution experience of clinic-molecular characterisation and correlation with treatment outcomes in patients with advanced extrapulmonary high grade neuroendocrine carcinomas: The NIRVANA study

#4046

Introduction: The gene mutation profiles of extra-pulmonary (EP) neuroendocrine carcinomas (NECs) and mixed neuroendocrine / non-neuroendocrine carcinomas (MiNENs) are incompletely understood.

Aim(s): The purpose of this study is to retrospectively characterize the clinical and molecular features of EP-NECs and MiNENs consecutive assessed at European Institute of Oncology (Milan).

Materials and methods: Surgical/biopsies specimens of advanced EP-NECs and MiNENs were examined by clinical and morphological features review. All tumor samples were also evaluated by IHC for microsatellite instability (MSI) analyses and 26-gene panel by next-generation sequencing (NGS) using a targeted multi-genes panel.

Conference:

Presenting Author: Spada F

Authors: Spada F, Pisa E, Ranghiero A, Frassoni S, Bagnardi V,

Keywords: NEC, MiNEN, NGS, KRAS, TP53, MSI, extra-pulmonary,