Abstract Library
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ENETS Abstract Search
#2936 Mutational Landscape of 109 High-Grade Gastroenteropancreatic Neuroendocrine Neoplasms G3
Introduction: Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) G3 are rare with a poor outcome. Molecular data for GEP NEN G3 is limited and the 2019 WHO classification is based on morphology and proliferation rate.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author: Elvebakken H
Authors: Venizelos A, Elvebakken H, Perren A, Hjortland G, Sundlöv A,
Keywords: molecular genetics, neuroendocrine carcinoma, neuroendocrine tumors, gastroenteropancreatic, mutations,
#2297 Merkel Cell Carcinomas in New Zealand: Virus or Ultra Violet?
Introduction: Merkel Cell Carcinoma (MCC) is a rare Neuroendocrine skin tumour. MCC behavior is more aggressive than the more common Melanoma, with treatments often restricted to surgery or radiotherapy, although immunotherapy holds promise overseas. In 2008, a USA study identified an oncogenic polyomavirus (MCPyV) present in eight of ten tested MCC tumours. Studies from across Europe and the USA confirmed MCPyV presence in ~80% of all MCCs. However, a cohort from Australia found a rate of just 24%, suggesting an alternative mechanism; ultra violet (UV) exposure was suspected and later confirmed using genomic mutational signature analysis. Are these are two separate diseases, requiring different clinical management strategies for best patient outcomes?
Conference: 15th Annual ENETSConcerence (2018)
Presenting Author: Robb T
Authors: Robb T, Woodhouse B, Parker K, Miller R, Hayward G,
Keywords: merkel, ddPCR, diagnostics, genomics,
Introduction: Diagnostic differentiation of uncommon pancreatic malignancies can be challenging, but is essential for accurate clinical management; genomic analysis may provide a tool for making this critical distinction.
Conference: 15th Annual ENETSConcerence (2018)
Presenting Author: Lawrence B
Authors: Robb T, Yeong M, Kramer N, Blenkiron C, Parker K,
Keywords: precision medicine, diagnostics, histology, pathology, histo-pathology, genomics,
Introduction: NECs of colon origin are orphan and highly aggressive neoplasms with limited molecular knowledge.
Conference: 15th Annual ENETSConcerence (2018)
Presenting Author: Capdevila J
Authors: Capdevila J, Mancuso F, Landolfi S, Martinez-Cardus A, Barriuso J,
Keywords: Neuroendocrine carcinoma, Genomics, Epigenomics, BRAFV600E, Patient-derived xenograft,
Introduction: Microsatellite instability (MSI) has been reported to occur in a significant proportion of neuroendocrine carcinoma (NEC) and mixed adenoneuroendocrine carcinomas (MANEC) (11 out of 89 cases, Sahnane et al, ERC 2015). It might be predictive of response to immunotherapy.
Conference: 14th Annual ENETSConcerence (2017)
Presenting Author: Hadoux J
Authors: Hadoux J, Malka D, Berdeloux A, Planchard D, Boige V,
Keywords: Neuroendocrine carcinoma, mismatch repair, microsatellite instability,