A systematic review of clinical prediction models for recurrence in patients with resectable grade 1 and 2 non-functional pancreatic neuroendocrine tumors

#3484

Introduction: The survival of patients with non-functional pancreatic neuroendocrine tumors (NF-pNET) is significantly impacted by recurrence. Accurate risk-stratification to identify patients at risk for recurrence can help tailor follow-up but may also reduce follow-up in patients with a low recurrence risk.

Aim(s): To provide an overview of the current state of developed clinical prediction models for recurrence in grade 1 and 2 NF-pNET.

Materials and methods: This systematic review followed the PRISMA and CHARMS guidelines. PubMed, Embase and the Cochrane Library were searched up to June 2021. Studies that developed, updated or validated prediction models for recurrence or overall survival in resected grade 1 or 2 NF-pNET were included. Exclusion criteria were reviews and abstracts, or if more than 15 per cent of pNET were functional, genetic or metastatic. Studies were critically appraised.

Conference:

Presenting Author: Chen J

Authors: Chen J, Heidsma C, Kabaktepe E, van Dieren S, Besselink M,

Keywords: pancreatic, neuroendocrine, tumor, non-functional, prediction, model, systematic, review, recurrence,