Accuracy of intra-operative beta probe in GEP-NET patients – Preliminary data from a prospective study

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Introduction: An accurate identification of GEP-NENs localization is crucial to achieve radical surgery. Radio guided surgery (RGS) is considered an innovative and promising surgical procedures that could help to identify smallest lesions.

Aim(s): We primary aimed to study the accuracy of intra-operative beta-probe in terms of sensibility and specificity with the pathology as gold standard. Secondary aim was to describe the intraoperative feasibility and safety of the RGS.

Materials and methods: This is a prospective study. Inclusion criteria were: 1) diagnosis of GEP-NEN eligibly for radical surgery; 2) positive Somatostatine-analogue-PET(SSA-PET) performed within the previous 4 weeks; 3) >18yo. Exclusion criteria were: 1) not eligible for a radical surgery; 2) SSA-PET not performed. Activity of 1.1 MBq/Kg was intravenously administered 10 minutes before the surgical cut. A beta-probe hand-held by the surgeon has been used to detect the tumor lesions’ emitted radiation. ROC curve analysis was used to calculate the CPS cut-off with the highest accuracy.

Conference:

Presenting Author: Mattana F

Authors: Mattana F, Zuccotti G, Barone A, Muraglia L, Collamati F,

Keywords: radio-guided-surgery, Nuclear medicine, GEP-NEN, surgery,