Assessment of the Serum Levels of the Soluble Vascular Cellular Adhesion Molecule-1 (sVCAM-1) in Patients with Neuroendocrine Neoplasms


Introduction: Tumor growth and the ability to metastasize is a multistage process involving interactions between cancer cells and the vascular endothelium. These interactions have been reported to be mediated by various molecules including sVCAM-1. We have previously shown elevated serum concentration of sVCAM-1 in 82 neuroendocrine neoplasms (NEN) compared to controls. Here, we present results of the extension of the previous study.

Aim(s): To assess serum concentration of sVCAM-1 in extended cohort of NEN stratified into sub-groups based upon clinicopathological characteristics (TNM stage, tumor grade).

Materials and methods: The study group comprised 151 patients with NEN (PNEN 18%, SBNEN 15%, rectal NEN 16%, gastric NEN 9%, lung NEN 18%, CUP 13%, other 11%), and 28 sex and age-matched healthy controls. NEN at TNM stage I comprised 38%, stage II: 5%, stage III: 5%, stage IV: 52%. 61% of NEN were G1, G2: 21%, and G3: 18%.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Malczewska A

Authors: Rosiek V, Malczewska A, Kos-Kudła B,

Keywords: neuroendocrine neoplasms, adhesion molecule, metastasis,

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