Calcitonin secreting neuroendocrine neoplasms of the lung: A systematic review

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Introduction: Calcitonin (CTN) secreting neuroendocrine neoplasms (NEN) of the lung are rare, with few cases reported in the literature. Differentiating between medullary thyroid carcinoma (MTC) and ectopic source of calcitonin secretion can represent a complex diagnostic conundrum for managing physicians with cases of unnecessary thyroidectomy reported in the literature.

Aim(s): To report a case of ectopic calcitonaemia from a metastatic neuroendocrine neoplasm of the lung with concurrent thyroid disease and summarise the results of a systematic review of the literature.

Materials and methods: This search was developed according to the Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P), and followed methods outlined in The Cochrane Handbook for Systematic Reviews of Intervention. Two reviewers conducted systematic searches of the following databases: MEDLINE, EMBASE, CENTRAL, ClinicalTrials.gov and SCOPUS. Our key Medical Subject Heading search terms were: “paraneoplastic” OR “ectopic” OR “neuroendocrine” AND “calciton…” AND “lung”.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Llewellyn D

Authors: Llewellyn D, Srirajaskanthan R, Guy C, Ramage J, Dimitriadis G,

Keywords: Calcitonin, Ectopic, lung, NEN, systematic review,