Abstract Library
Welcome to the open-access search for all ENETS abstracts presented at the Annual ENETS Conferences.
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Introduction: Pancreatic neuroendocrine tumors (PNETs) are mostly indolent but can achieve malignancy. Surgery is the only approved first-line therapy. Kinase inhibitors and radiotherapy for unresectable PNETs are non-curative and targeted therapies are currently lacking for PNETs. However, immune checkpoint inhibitors have created a paradigm shift in cancer therapy with significant increase in overall survival, but are curative only in a subset of patients, partly due to limited T cell infiltration, especially in angiogenic and cold tumors like PNETs. Parallelly, antiangiogenic therapy increases lymphocyte infiltration by normalising the tumor vasculature. Tallying antiangiogenic to immunotherapies (AI) has provided improved survival benefits for patients of advanced RCCs and HCCs, while other cancers like glioblastoma remain highly resistant.
Conference:
Presenting Author:
Authors: John Robbert D, Guyot M, Killian T, Verslype C, Lambrechts D,
Keywords: Pancreatic neuroendocrine tumor, Antiangiogenic immunotherapy, single cell transcriptomics, Immunosuppression,
#3321 Calcitonin secreting neuroendocrine neoplasms of the lung: A systematic review
Introduction: Calcitonin (CTN) secreting neuroendocrine neoplasms (NEN) of the lung are rare, with few cases reported in the literature. Differentiating between medullary thyroid carcinoma (MTC) and ectopic source of calcitonin secretion can represent a complex diagnostic conundrum for managing physicians with cases of unnecessary thyroidectomy reported in the literature.
Conference: 18th Annual ENETS Concerence (2021)
Presenting Author: Llewellyn D
Authors: Llewellyn D, Srirajaskanthan R, Guy C, Ramage J, Dimitriadis G,
Keywords: Calcitonin, Ectopic, lung, NEN, systematic review,
Introduction: A new formulation of octreotide LAR (OCT LAR) with a new diluent has been developed to facilitate the preparation and administration.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author: Coriat R
Authors: Cadiot G, Coriat R, Raverot G, Nguyen Tan Hon T, Raingeard I,
Keywords: Octreotide LAR, NET, Acromegaly, Nurse,
Introduction: Recent studies in pancreatic neuroendocrine tumors have identified mutations in DAXX/ATRX, MEN1, and genes involved in the phosphoinositide-3-kinase/Akt/mammalian target of rapamycin (PI3K-Akt-mTOR) pathway. However, these studies focused on abundant mutations.
Conference: 15th Annual ENETSConcerence (2018)
Presenting Author: Vandamme T
Authors: Vandamme T, Beyens M, Van Camp G, Boons G, Hofland L,
Keywords: pancreatic neuroendocrine tumors, PNET, genetics, tumor heterogeneity, hotspot mutations,
Introduction: Cancer driver mutations affecting the histone H3.3 chromatin remodellers ATRX and DAXX were recently discovered in 43% of sporadic pancreatic neuroendocrine tumours (PNET). Progressive age-dependent replacement of canonical H3.1/2 with H3.3 is crucial for maintaining genome integrity through expression of repressive markers at heterochromatic sites, where loading is mediated by ATRX and DAXX. Loss of H3.3 chaperones in PNET is associated with activation of ALT, a telomere maintenance mechanism, eventually leading to chromosome instability. It has been suggested that ATRX/DAXX expression is necessary for repressing ALT, but mechanistic details of this interaction are not fully understood.
Conference: 15th Annual ENETSConcerence (2018)
Presenting Author: Sposito T
Authors: Sposito T, C Nguyen Tu M, Thirlwell C, Salomoni P,
Keywords: PNET, mouse model, epigenetic,