Cancer associated fibroblasts induce proliferation and therapeutic resistance in neuroendocrine tumors through STAT3 activation

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Introduction: Cancer-associated fibroblasts (CAF) have been identified as relevant contributors to cancer progression and drug resistance in many tumors. Although neuroendocrine tumors (NET) are often associated with a strong stromal reaction, no study has addressed whether CAF are involved in progression and therapeutic resistance in NET.

Aim(s): The aim of this study was to characterize the role of CAF in NET.

Materials and methods: We established primary CAF cultures derived from NET liver metastases to study the effect on NET cell lines NT-3 and BON. Immunohistochemistry was performed on tissue sections of primary and metastatic NET tissue.

Conference:

Presenting Author:

Authors: Amin T, Viol F, Fahl M, Eggers C, Awwad F,

Keywords: neuroendocrine tumor, cancer associated fibroblasts, NT-3, cell lines,