Carcinoid crisis: Insights from an ENETS Center of Excellence

#4303

Introduction: Neuroendocrine neoplasms (NENs) are rare tumours, with up to 30% being functional and associated with carcinoid syndrome (CS). CS commonly presents with flushing, diarrhoea, and hemodynamic instability, and can progress to carcinoid crisis (CC), a severe, potentially fatal complication during surgery or other invasive procedures. The use of prophylactic octreotide infusion peri-operatively remains controversial. The lack of a universal CC definition also poses a challenge for standardised outcome assessments.

Aim(s): We aim to evaluate the prevalence, characteristics, and treatment outcomes of CC in CS patients undergoing procedures using broad (severe hypotension, hypertension, arrhythmias) and stringent (systolic BP < 80 mmHg > 10 minutes) definitions for CC.

Materials and methods: A retrospective study was conducted at Peter MacCallum Cancer Center in CS patients who underwent procedures between January 2019 and December 2023.

Conference:

Presenting Author: Del Olmo-Garcia M

Authors: Del Olmo-Garcia M, Kong G, Wong H, Michael M, Ismail H,

Keywords: carcinoid syndrome, carcinoid crisis, somatostatin analogue, peri-operative management,