Colorectal NECs and MANECs: A monocenter pilot retrospective analysis

#3129

Introduction: Poorly-differentiated neuroendocrine carcinomas (NECs) and mixed adeno-neuroendocrine carcinomas (MANECs) are rare and aggressive neoplasms whose tumorigenesis pathways are still unknown and clinical management not universally shared.

Aim(s): We evaluated genetic alterations that might suggest pathways of carcinogenesis, neuroendocrine(NE) differentiation and possible targets for future therapies.

Materials and methods: We retrospectively reviewed clinical and pathologic data of colorectal(cr) NECs and MANECs patients(pts) treated at our Institute between 2015 and 2019.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author:

Authors: Laffi A, Spada F, Ranghiero A, Pisa E, Barberis M,

Keywords: mutational, genetic, neuroendocrine, NEC, MANEC, carcinogenesis, colorectal,