Correlation of Serum Chromogranin A Change with Radiographic Response in Patients with Non-Functioning Advanced Neuroendocrine Tumors

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Introduction: Numerous studies have suggested that CgA determination may be useful for the diagnosis and follow-up of neuroendocrine tumors (NETs).

Aim(s): To determine the sensitivity of CgA in diagnosis of non-functioning NETs, and the correlation of CgA change with radiographic response in patients with advanced non-functioning NETs.

Materials and methods: Serial CgA determinations were performed in 29 patients (24 pNETs, five others, 80 visits) with locally advanced (n=3) or metastatic (n=26) non-functioning NETs on various treatments. Changes in CgA levels over 25% were considered as significant. CT and/or MRI were performed at each visit for response determination using RECIST 1.1 criteria.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Cheng Y, Sun Z, Bai C, Ying H, Meng C,

Keywords: CgA change, radiographic response, nonfunctioning NETs,