Abstract Library

#4381 TOPK promotes tumorigenesis and metastasis of pancreatic neuroendocrine neoplasms by enhancing the MAPK signalling pathway

Introduction: T-LAK cell-originated protein kinase (TOPK) is highly expressed in pancreatic neuroendocrine neoplasms (pNENs) with liver metastasis and is associated with a poor prognosis.

Conference:

Presenting Author: Chen Q

Authors: Chen Q, Yuan M, Meng M, Ren S, Li G,

Keywords: TOPK, Pancreatic Neuroendocrine Neoplasm, MAPK signalling pathway, Invasion and metastasis, HI-TOPK-032,

#4361 Identification of IRS2 as a prognostic and therapeutic target in gastrointestinal neuroendocrine tumours

Introduction: Intestinal neuroendocrine tumours (INETs) are rare malignancies characterised by diverse clinical outcomes. In our previous research, high expression of IRS2 was associated with poor prognosis in gastric neuroendocrine tumours, but its role in intestinal neuroendocrine tumours remains unclear.

Conference:

Presenting Author:

Authors: Zhang M, Li S,

Keywords: gastrointestinal neuroendocrine tumour, IRS2, tumour progression,

#4347 Mixed neuroendocrine non-neuroendocrine neoplasm associated with gastric autoimmunity: A clinicopathological analysis of two cases

Introduction: Two cases of mixed neuroendocrine tumour - gastric adenocarcinoma were found in patients with autoimmune atrophic gastritis. Both components expressed synaptophysin, initially suggesting a neuroendocrine tumour diagnosis. However, further examination confirmed the presence of gastric adenocarcinoma of fundic gland type.

Conference:

Presenting Author:

Authors: Huang D, Chen X, Chu J, Ma M,

Keywords: Mixed neuroendocrine tumour, autoimmune atrophic gastritis, gastric adenocarcinoma of fundic gland type,

#4291 Novel genomic score predicts survival with immune checkpoint blockade in neuroendocrine neoplasms

Introduction: Immune checkpoint inhibition (ICI) has activity in Grade 3 (G3) neuroendocrine neoplasms (NENs) but predictive biomarkers of overall survival (OS) are currently lacking.

Conference:

Presenting Author:

Authors: Brar T, Sukrithan V, Le D, Xu M, Olowookere C,

Keywords: Neuroendocrine Neoplasm, Immunotherapy, Ipilimumab, Nivolumab, Immune checkpoint inhibitor, biomarker, genomic score,

#4280 Predictive and prognostic nomogram models for liver metastasis in colorectal neuroendocrine neoplasms: A large population study

Introduction: The incidence of patients with colorectal neuroendocrine neoplasms (CRNENs) is continuously increasing. Most patients have distant metastases when diagnosed. Liver metastasis (LM) is the most common type of distant metastasis, and the prognosis is poor once LM occurs. However, there is still a lack of effective models for predicting the risk and prognosis of LM in CRNENs.

Conference:

Presenting Author: Song L

Authors: Lei X, Su Y, Lei R, Zhang D, Liu Z,

Keywords: colorectal neuroendocrine neoplasm, liver metastasis, overall survival, nomogram, SEER, prognostic factor, risk factor,