Diagnostic role and prognostic value of tumor markers in high-grade GEP-NENs

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Introduction: High-grade gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) can be divided into well differentiated neuroendocrine tumors G3 (NETs G3) and poorly differentiated neuroendocrine carcinomas (NECs). Diagnostic and prognosis value of tumor markers in this entity still remains unknown.

Aim(s): The purpose of this study is to explore value of 8 tumor markers (including CA19-9, CA125, CEA, CA724, AFP, SA, NSE and SCC) in differential diagnosis and and prognosis of high-grade GEP-NENs.

Materials and methods: A total of 103 patients diagnosed with high-grade GEP-NENs were recruited in this study, 73 patients owning the data of tumor markers were further studied. Demographics, clinicopathological characteristics, and survival data were collected and analysed. Kaplan–Meier methods and Log rank tests were used to compare survival rate, a Cox regression model was used to accomplish multivariate analyses.

Conference:

Presenting Author: Gao C

Authors: Gao C, Fan Z, Yang J, Shi M, Liu S,

Keywords: CA-19-9 Antigen, Carcinoembryonic Antigen, overall survival, gastroenteropancreatic neuroendocrine neoplasm,