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Downgrading Due to Ki-67 Index Assessment with Image Analysis


Introduction: The latest WHO classification for neuroendocrine tumors (NET) defines their grade according to Ki-67 and mitotic index. These parameters have both shown to be prognostic.

Aim(s): We investigate the accuracy of the Ki-67 index for grading NET.

Materials and methods: Ki-67 index of 82 tumor specimens of NET was assessed by two pathologists as in routine practice with the eyeballing method and twice by image analysis using ImageJ. For image analysis, photomicrographs of Ki-67 stained slides taken at a magnification of 20 and 40 were used.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author: van Velthuysen M

Authors: Van Velthuysen M, Korse T, Sanders J, Prins F,

Keywords: neuroendocrine tumors, image analysis, Ki-67, grading,

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