Efficacy of 177Lu-octreotate in biliary duct neuroendocrine tumor

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Introduction: We report the case of a 69-year-old woman presenting a biliary duct neuroendocrine tumor, diagnosed in 2003 treated by extrahepatic biliary tract resection.

Aim(s): A nodal hepatic hilar recurrence occurred in 2014. The biopsy confirmed a grade 2 well-differentiated neuroendocrine tumor (Ki-67 3%), leading to the initiation of treatment with Somatostatin Analogues until tumor progression in May 2016.

Materials and methods: Therefore, the patient has been treated with four cycles of 7,4GBq of 177Lu-octreotate until April 2017 as all tumor localisations showed a significant uptake at SRS. The post-treatment CT evaluation showed a partial response on the nodal localisations (7cm vs 10cm previously, RECIST -26%) and we noticed a significant decrease of CgA (442ng/ml in April 2017 vs 1096 ng/ml in November 2016).

Conference:

Presenting Author:

Authors: Kelly A, Otman H, Petorin C, Perret-Boire S, Chanchou M,

Keywords: 177Lu-octreotate, biliary duct neuroendocrine tumor,