Epigenetic exploration of mesenteric fibrosis indicates epigenetic disruption of DAXX is driving metastatic potential in small intestinal neuroendocrine tumours

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Introduction: Up to 50% of patients diagnosed with small intestinal neuroendocrine tumours (SI-NETs) are affected by mesenteric fibrosis (MF) which has significant pathological effects and impacts patient mortality.

Aim(s): To assess the role of DNA methylation in development of different grades of mesenteric fibrosis in SI-NETs.

Materials and methods: Genome-wide DNA methylation was assessed for 115 samples from 42 patients who were categorised as having ‘no MF’, ‘minimal MF’, ‘mild MF’ or ‘severe MF’ using histopathology. Methylation patterns were compared between primary tumours, metastatic mesenteric mass and matched small intestinal tissue for each patient.

Conference:

Presenting Author: Webster A

Authors: Webster A, Martins M, Hodgetts H, Feelders R, Hofland L,

Keywords: DNA methylation, SI-NET, Mesenteric fibrosis, Epigenetics, Gene regulation, DAXX,