Expression and Clinical Significance of Merkel Cell Polyomavirus Large T Antigen in Merkel Cell Carcinoma

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Introduction: Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin cancer that is often associated with Merkel cell polyomavirus (MCPyV) infection. MCPyV expression and its relationship with clinical features and prognosis in MCC remain unclear.

Aim(s): The aim of the study was to investigate the frequency and pattern of the MCPyV expression in primary and metastatic tumors from patients with MCC and evaluate the role of MCPyV in prognosis of MCC.

Materials and methods: Merkel cell polyomavirus Large T antigen (MCPyV) expression was evaluated by immunohistochemistry with the monoclonal antibody CM2B4 in 32 pathologically confirmed MCC cases and correlated with clinicopathological parameters of patients.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author:

Authors: Delektorskaya V, Orlova K, Smirnova E, Demidov L,

Keywords: merkel cell carcinoma, merkel cell polyomavirus, immunohistochemistry, prognosis,