Expression of Netrin-1 and its Receptors in pNETs

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Introduction: Netrin-1, a member of axon guidance molecules, and its dependence receptors (DCC, UNC5, neogenin) is involved in several cancer types (breast, neuroblastoma, colon etc) but its role in pNETs remains unknown.

Aim(s): Our aim was to determine the expression pattern of netrin-1 and its receptors in pNETs and to correlate with histoprognostic factors and evolution.

Materials and methods: Immunohistochemistry was performed on a Tissue Micro Array composed of 70 pNETs. Frozen samples of 25 pNETs (six insulinomas and 19 non-secreting tumors) were analyzed by RT-qPCR. We also assessed the expression of netrin-1 and its receptors in cell lines representative of pNETs.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Benslama N, Bollard J, Massoma P, Vercherat C, Hervieu V,

Keywords: netrin-1, pNET, progression,