Abstract Library
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ENETS Abstract Search
Introduction: Small intestinal neuroendocrine tumors (siNETs) are rare tumors that raise several clinical and therapeutic challenges. Current treatments are not efficient, in part because of a poor understanding of their mechanisms of progression. We recently highlighted some axon guidance molecules (AGMs) that might be implicated in the progression of siNETs. Among them, we are currently focusing our efforts on the semaphorin 3F receptor neuropilin-2 (NRP2).
Conference: 14th Annual ENETSConcerence (2017)
Presenting Author:
Authors: Bollard J, Massoma P, Patte C, Carbonnaux M, Vercherat C,
Keywords: siNETs, progression, NRP2 ,
#1166 mTOR Pathway Inhibition Sensitizes Insulinoma Cells to Streptozotocin Induced Apoptosis
Introduction: Pancreatic neuroendocrine tumors (pNETs) are generally chemoresistants probably due to low proliferation rate and defects in apoptotic pathway. Targeted therapies are new encouraging options for pNETs however; clinical trials show limited objective response. Combination of chemotherapy and targeted therapy could be a new solution in therapeutic care. Streptozotocin (STZ) is the 1st line of therapy for unresectable pNETs.
Conference: 12th Annual ENETSConcerence (2015)
Presenting Author: Vercherat C
Authors: Vercherat C, Walter T, Massoma-Peh P, Bollard J, Lacheretz-Bernigaud A,
Keywords: neuroendocrine, therapy, Streptozotocin, mTOR pathway, combination, pre-clinical study,
Introduction: Several systemic treatments are available for metastatic neuroendocrine Tumors (NETs), including everolimus, but there is no predictive factor of response to these treatments.
Conference: 12th Annual ENETSConcerence (2015)
Presenting Author: Walter T
Authors: Benslama N, Bollard J, Vercherat C, Roche C, Hervieu V,
Keywords: neuroendocrine tumors, everolimus, markers, p-p70S6K,
#604 Expression of Netrin-1 and its Receptors in pNETs
Introduction: Netrin-1, a member of axon guidance molecules, and its dependence receptors (DCC, UNC5, neogenin) is involved in several cancer types (breast, neuroblastoma, colon etc) but its role in pNETs remains unknown.
Conference: 10th Annual ENETSConcerence (2013)
Presenting Author:
Authors: Benslama N, Bollard J, Massoma P, Vercherat C, Hervieu V,
Keywords: netrin-1, pNET, progression,
Introduction: Semaphorin family, a part of axon guidance molecules, is involved in many types of epithelial cancers. However, little is known about its potential function in GEP-NETs.
Conference: 10th Annual ENETSConcerence (2013)
Presenting Author:
Authors: Bollard J, Massoma P, Blanc M, Vercherat C, Lepinasse F,
Keywords: semaphorins, progression, biomarker,