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Implication of Neuropilin-2 in the Progression of Small Intestinal Neuroendocrine Tumors: Towards a Promising Therapeutic Target?
Introduction: Small intestinal neuroendocrine tumors (siNETs) are rare tumors that raise several clinical and therapeutic challenges. Current treatments are not efficient, in part because of a poor understanding of their mechanisms of progression. We recently highlighted some axon guidance molecules (AGMs) that might be implicated in the progression of siNETs. Among them, we are currently focusing our efforts on the semaphorin 3F receptor neuropilin-2 (NRP2).
Aim(s): The aim is to validated NRP2 as a therapeutic target.
Materials and methods: A tissue microarray gathering 34 cases of siNETs has been utilized to assess NRP2 expression. NRP2 serum level has been dosed in patients. In vitro, NRP2 expression has been silenced in the STC-1 cell line. An in vivo mouse model of tumor cell dissemination has also been used.
Conference: 14th Annual ENETSConcerence (2017)
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