External validation of Rachel score: A prognostic tool for lung neuroendocrine tumours

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Introduction: Lung NETs are a heterogeneous group of tumours with variegated clinical presentation and course. The histological subtype (TC vs AC) and TNM stage are established prognostic factors. In a previous work by our group, we developed a prognostic model named Rachel score, with a satisfactory ability to predict OS and PFS in this population.

Aim(s): We selected a lung NET patients’ external cohort to validate the Rachel score.

Materials and methods: This cohort included 121 lung NET: median age 59 years, 41 male sex (33.88%), 43 left-sided tumours (35.54%), 20 positive nodal status (16.53%), 54 AC (44.63%), 20 with necrosis (16.53%), median Ki-67: 7. Median OS: 89 months, median PFS: 72 months. Ki-67 value was missing in 31 cases (25.62%).

Conference:

Presenting Author: La Salvia A

Authors: La Salvia A, Marcozzi B, Lamberti G, Manai C, Mazzilli R,

Keywords: lung neuroendocrine tumour, prognostic tool, Rachel score, external cohort, validation,