Fibroblast Activation Protein (FAP)-directed molecular imaging segregates between subtypes of poorly differentiated neuroendocrine neoplasms

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Introduction: Fibroblast activation protein (FAP) is overexpressed in highly aggressive gastroenteropancreatic neuroendocrine neoplasms (NEN).

Aim(s): We aimed to elucidate the performance of non-invasive FAP inhibitor-directed PET/CT when compared to [18F]FDG in patients with poorly differentiated NEN and to identify patients eligible for a FAPI-directed endoradiotherapy (ERT).

Materials and methods: Nine treatment-naive patients with high grade NEN [neuroendocrine tumor (NET) G3, neuroendocrine Carcinoma (NEC), and mixed-adeno-neuroendocrine malignancies (MiNEN), n=3, each] underwent [68Ga]FAPI and [18F]FDG PET/CT. Patient- and lesion-based image analyses were conducted and compared to immunohistochemistry (IHC) investigating FAP and somatostatin receptor (SSTR) 2.

Conference:

Presenting Author: Weich A

Authors: Weich A, Wild V, Higuchi T, Meining A, Rowe S,

Keywords: [68Ga]FAPI, fibroblast activation protein, neuroendocrine, molecular imaging, ert,