Grade 3 neuroendocrine neoplasms – Real life experience and prognostic biomarkers

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Introduction: Grade 3 neuroendocrine neoplasms (G3 NEN) are a heterogeneous group, including well differentiated tumors (NET) and poorly differentiated carcinomas (NEC), whose identification can be challenging. Accessible prognostic tools are needed to individualize treatment. Data suggests neutrophil/lymphocyte ratios (NLR) and systemic inflammatory index (SII) have prognostic value in NEN.

Aim(s): Primary endpoint was demographic characterization of the population and survival analysis. Secondary endpoint was to evaluate Ki67, NLR and SII impact on OS.

Materials and methods: We retrospectively analysed G3 NEN from January 2015 to April 2021. NLR and SII (NLR x Platelets) were calculated before starting first-line treatment. A cut-off of 4 and 698 was used, respectively, according to literature.

Conference:

Presenting Author: Rebordão Pires M

Authors: Rebordão Pires M, Monteiro J, Amorim Costa C, Caetano A, Elvas A,

Keywords: Grade 3 neuroendocrine neoplasm, NEC, NET, Neutrophil to lymphocyte ratio, Systemic Inflammatory Index, Ki67, Prognostic biomarker,