Hypoglycaemia in a Patient with Glucagonoma-Coincidence of a Glucagonoma and Insulinoma in a Patient with Multiple Endocrine Neoplasia Type I
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Introduction: We report the case of a 54 year old female with a known MEN1 syndrome with primary Hyperparathyroidism, a Prolactinoma and a pancreatic tumor. The patient complains about episodes of fatigue and sweating, both symptoms improve immediately after a meal.
Aim(s): Lab tests show a fasting glucose of 45 mg/dl, (without hypoglycaemic symptoms). A MRI of the pancreas shows a tumor with typical radiologic characteristics of a pancreatic neuroendocrine Tumor (PNET) with an increasing diameter from 22 to 27 mm (compared to one year ago). Further lab tests show an elevated glucagon level with 942 pg/ml (- 250 pg/ml). Insulin and C-peptide values were in the lower normal range.
Materials and methods: Due to the clinical symptoms and the increase in tumor size a left sided pancreatectomy and splenectomy was performed.
Conference: 12th Annual ENETSConcerence (2015)
Presenting Author:
Authors: Ploner F, Plank J, Humer-Fuchs U, Lax S, Noggler P,
Keywords: MEN1, Glucagonoma,
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