Immune landscape of small intestinal neuroendocrine tumor at single-cell level

#4066

Introduction: Small intestinal neuroendocrine tumor (SI-NET) is the most common malignant tumor of the small intestine. Despite its prominence, a full understanding of the immune landscape in SI-NET remains elusive.

Aim(s): We aim to delve into the immune atlas of SI-NET and unravel the mechanisms contributing to the limited immunotherapy efficacy in SI-NET.

Materials and methods: Five matched samples underwent single-cell RNA sequencing (scRNA), which was complemented by integrating one publicly available SI-NET scRNA data. Immunohistochemistry staining was performed for validation.

Conference:

Presenting Author: Lin X

Authors: Lin X, Chen L, Liu M, Li Y, Wen W,

Keywords: small intestinal neuroendocrine tumor, single-cell RNA sequencing, immunosuppressive, CD8 T cells, TGFB1,