Abstract Library
Welcome to the open-access search for all ENETS abstracts presented at the Annual ENETS Conferences.
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ENETS Abstract Search
Introduction: Indoleamine-2,3-dioxygenase (IDO) converts L-tryptophan (T) to L-kynurenine (K) resulting in an immunosuppressive microenvironment.
Conference:
Presenting Author: Mancini C
Authors: Mancini C, Pecora G, Salerno G, Lionetto L, Visco V,
Keywords: Neuroendocrine Tumour, tryptophan, kynurenine, cytokines, immunotherapy, Indoleamine-2-3-dioxygenase,
Introduction: The growth pattern of a tumour is a marker for distinguishing inert from invasive tumours. In general, tumours such as the encapsulated follicular variant of papillary thyroid carcinoma show expansive growth. In contrast, invasive tumours, such as colorectal cancer and squamous cell carcinoma of the tongue, show invasive growth with infiltration into surrounding structures and have a poorer prognosis. Pancreatic neuroendocrine neoplasm (PNEN) is the heterogeneous tumour originating from peptidergic neurons and neuroendocrine cells. PNEN with a high proportion of tumour mesenchyme, especially those presenting an infiltrating stroma, have a poor prognosis. In the infiltrating mesenchyme, cancer-associated fibroblasts (CAF) play an important role. However, little research has been done on the mechanisms of how infiltrating CAF affects tumour malignancy and immune microenvironment.
Conference:
Presenting Author: Wang Y
Authors: Wang Y, Xu J, Chen J, Xu X, Ji S,
Keywords: pancreatic neuroendocrine neoplasm, tumour-associated fibroblasts, immunosuppressive microenvironment,
Introduction: Indoleamine 2,3-deoxygenase (IDO) enzyme, by inducing L-tryptophan (Trp) depletion and L-kynurenine (kyn) accumulation, contributes to the formation of an immunosuppressive microenvironment. Some studies highlighted that patient with cancer in treatment with immune checkpoint inhibitors (ICI) and with low Kyn/Trp values showed a better PFS and OS, but there are no data for NETs.
Conference:
Presenting Author: Mancini C
Authors: Mancini C, Mazzilli R, Zamponi V, Motta C, Salerno G,
Keywords: neuroendocrine tumor, IDO enzyme, Kyn/Trp ratio, immunotherapy,
#4066 Immune landscape of small intestinal neuroendocrine tumor at single-cell level
Introduction: Small intestinal neuroendocrine tumor (SI-NET) is the most common malignant tumor of the small intestine. Despite its prominence, a full understanding of the immune landscape in SI-NET remains elusive.
Conference:
Presenting Author: Lin X
Authors: Lin X, Chen L, Liu M, Li Y, Wen W,
Keywords: small intestinal neuroendocrine tumor, single-cell RNA sequencing, immunosuppressive, CD8 T cells, TGFB1,
Introduction: Pancreatic neuroendocrine tumors (PNETs) are mostly indolent but can achieve malignancy. Surgery is the only approved first-line therapy. Kinase inhibitors and radiotherapy for unresectable PNETs are non-curative and targeted therapies are currently lacking for PNETs. However, immune checkpoint inhibitors have created a paradigm shift in cancer therapy with significant increase in overall survival, but are curative only in a subset of patients, partly due to limited T cell infiltration, especially in angiogenic and cold tumors like PNETs. Parallelly, antiangiogenic therapy increases lymphocyte infiltration by normalising the tumor vasculature. Tallying antiangiogenic to immunotherapies (AI) has provided improved survival benefits for patients of advanced RCCs and HCCs, while other cancers like glioblastoma remain highly resistant.
Conference:
Presenting Author:
Authors: John Robbert D, Guyot M, Killian T, Verslype C, Lambrechts D,
Keywords: Pancreatic neuroendocrine tumor, Antiangiogenic immunotherapy, single cell transcriptomics, Immunosuppression,