IMP3 and Ki-67-Factors of Poor Clinical Outcome in Neuroendocrine Tumors of the Lung


Introduction: Insulin- like growth factor-II messenger RNA- binding protein- 3 (IMP3) is often detected in malignant neoplasm of different sites. Ki-67 proliferative index, although helpful in diagnosing neuroendocrine tumours of lung, has not been recognised as prognostic factor.

Aim(s): The aim of this study was to correlate both and determine their utility as prognostic markers, to identify patients at high risk of recurrence or metastasis and program further, prolonged follow-up.

Materials and methods: A total of 73 patients diagnosed with neuroendocrine tumour of lung and admitted to Thoracic Surgery Department in University Hospital in Zabrze were enrolled in the study. We identified 34 cases of typical carcinoids (TC; 47%), 15 cases of atypical carcinoids (AC; 20%) and 24 cases of large cell neuroendocrine carcinomas (LCNC; 33%). The mean follow- up was of 44 months. Twenty patients (27%) died within 21 months.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Bełz A, Stęplewska K, Głogowska- Szeląg J,

Keywords: carcinoid, IMP3, Ki-67, neuroendocrine,

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