Abstract Library

#3026 IMP3 and Ki-67-Factors of Poor Clinical Outcome in Neuroendocrine Tumors of the Lung

Introduction: Insulin- like growth factor-II messenger RNA- binding protein- 3 (IMP3) is often detected in malignant neoplasm of different sites. Ki-67 proliferative index, although helpful in diagnosing neuroendocrine tumours of lung, has not been recognised as prognostic factor.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Bełz A, Stęplewska K, Głogowska- Szeląg J,

Keywords: carcinoid, IMP3, Ki-67, neuroendocrine,

#1323 Expression of Oncofetal Protein IMP3 in Lymph Node Metastases of Small Intestine Neuroendocrine Neoplasms: A New Predictor of Recurrence

Introduction: Small intestine neuroendocrine neoplasm (SINENs) are heterogeneous neoplasms arising from endocrine cells of the intestinal mucosa. Ki67 is the main determinant of prognosis in NENs. However, the research for new prognostic makers represent a key-point. The oncofetal protein IMP3 plays a role in cell growth and its expression has a prognostic value in lung neoplasms.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Cavalcoli F

Authors: Massironi S, Del Gobbo A, Cavalcoli F, Fiori S, Conte D,

Keywords: IMP3, intestinal NENs,

#264 Alterations of TIMP-3 Gene in Insulinomas and Its Significance

Introduction: Our previous study on insulinoma found allelic loss of 22q12 where suppressor gene TIMP3 located. TIMP3 can inhibit tumor invasion or metastasis, but its clinical implications in insulinoma are unknown.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Chen Y, Zhou C, Wu H, Liu T, Xiao Y,

Keywords: insulinoma, TIMP-3 gene, allelic loss, biomarker,